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. 2021 Aug 3;64(15):11709–11728. doi: 10.1021/acs.jmedchem.1c01115

Table 3. DYRK1A Binding Affinity of Pyrazolo[1,5-b]pyridazines.

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a

pIC50 in TR-FRET-based ligand-binding displacement assay measured with two technical replicates (n = 1 biological replicate). LE = 1.4(pIC50)/nonhydrogen atoms. LLE = pIC50 – clog P.