Skip to main content
. 2021 Aug 3;64(15):11709–11728. doi: 10.1021/acs.jmedchem.1c01115

Table 7. SPR Measurement of Lead Compounds.

compound ka (M–1 s–1) kd (s–1) KD (nM)
9 7.3 (±0.1) × 106 0.97 (±0.02) 134.1 (±0.5)
10 6.0 (±0.1) × 106 0.33 (±0.1) 55.0 (±0.1)
11 2.8 (±0.1) × 106 0.24 (±0.01) 85 (±1)
12 6.3 (±0.2) × 106 0.57 (±0.01) 90.4 (±0.0.3)
22 3.9 (±0.4) × 106 0.25 (±0.03) 64 (±2)
33 2.2 (±0.1) × 106 0.16 (±0.01) 72.8 (±0.3)
34 1.8 (±0.1) × 106 0.12 (±0.02) 65.5 (±0.4)
95 4.7 (±0.1) ×106 0.06 (±0.01) 12.0 (±0.1)
105 1.6 (±0.1) × 106 1.58 (±0.02) 963 (±2)
109 2.9 (±0.1) × 106 0.44 (±0.01) 153.2 (±0.5)