Table 9. Selectivity Profiles of Lead Compounds^a.

compound	DYRK1A	DYRK1B	DYRK2	CLK1	CLK2	CLK3	CDK2	GSK3β	S score (35)
11	0.4	2.7	19	7.1	9.4	54	100	94	0.027
12	34	43	100	79	95	96	100	91	0.013
22	0.7	8.3	11	33	13	54	100	75	0.042
24	33	81	66	71	61	100	100	92	0.004
28	2.4	7.2	15	17	16	88	100	77	0.050
29	1.5	9.1	25	16	15	73	95	100	0.035
31	20	34	39	48	62	96	95	98	0.011
33	1.7	18	29	36	72	95	100	100	0.027
34	1.3	10	28	47	51	89	86	100	0.032
63	1.1	1.6	25	15	13	76	89	100	0.027
66	0.2	0.7	24	7.8	12	83	100	100	0.022
70	0.7	6.2	35	20	31	56	86	77	0.022
95	18	71	55	53	54	84	100	93	0.002

^a% Remaining activity as determined by DiscoverX KINOMEscan experiment. Inhibitor concentration = 1 μM.