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. 2021 Sep 16;6(38):25062–25075. doi: 10.1021/acsomega.1c04302

Table 3. EC50 and Emax Values for ATP/BzATP-Induced Response in the Absence and Presence of Different Concentrations of Inhibitor.

ATP/BzATP dose–response curve EC50 (μM) Emax (%)
h-P2X2R ATP without inhibitor 1.083 100
0.2 μM of 6h 1.014 82
0.6 μM of 6h 1.848 74
0.8 μM of 6h 1.413 51
h-P2X4R ATP without inhibitor 2.588 100
1 μM of 7e 1.634 73
3 μM of 7e 1.125 57
6 μM of 7e 2.192 43
h-P2X7R BzATP without inhibitor 5.497 100
0.5 μM of 6h 9.489 77
1.0 μM of 6h 5.724 55
2.0 μM of 6h 6.483 50