. 2021 Sep 16;6(38):25096–25108. doi: 10.1021/acsomega.1c04432

Table 1. Yield of Each Compound in the Steps of Schemes 1 and 2.

compd.	4 (%)	5 (%)	6 (%)	8 (%)	2 (%)	9 (%)	1 (%)
a	33	79	99	56	52	53	72
b	73	95	25	63	96^a	35	35
c	98	88	68	21	19	37	67
d	95	87	57	30	45	26^b	78
e	47	62	68	21	13

All-E configuration was deteriorated after deprotection (all-E:Z = 1.7:1).

The reaction was performed by one-pot double olefination between C₂₀ diphosphonate 10 and 4d (2 equiv).