Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 16;11:730413. doi: 10.3389/fcimb.2021.730413

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Jezewski, Lin, Reisz, Culp-Hill, Barekatain, Yan, D’Alessandro, Muller and Odom John

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanistic model of anti-parasitic selectivity of a host target. (A, B) Darker red indicates increased metHB formation, infected red cells are indicated by purple ring-stage parasites, erythrocyte membrane channels are plasmodium derived low selectivity permeability pathways, prodrug processing is indicated by cytosolic esterases (black) (A) The enolase inhibitor HEX exhibits low potency but is selectively targeted to host infected red blood cells to generate a therapeutic index. (B) The prodrug cognate POM-HEX increases potency but eliminates any therapeutic window.