Table 1.

Table of parasite EC₅₀s and methemoglobin EC₅₀s for all tested compounds and their structures.

Compound	Structure	Parasite EC50 (µM)	MetHb EC50 (µM)	T.I.	Parasite EC50 (µM)	MetHb EC50 (µM)	T.I.	T.I. Fold change
		- pyruvate			+ pyruvate
HEX		19 ± 1.0	500	26.3	18 ± 2.2	500	27.8	1.1
POM-HEX		2.9 ± 0.64	1.2 ± 0.19	0.4	0.91 ± 0.15	1.4 ± 0.11	1.5	3.7
POM-SF		0.71 ± 0.04	0.1 ± 0.002	0.1	0.25 ± 0.01	0.48 ± 0.01	1.9	13.6

Displayed are the means ± s.e.m from three or more independent biological replicates in the presence or absence of 1mM pyruvate. EC₅₀s are displayed at the highest concentration tested (500 µM) for instances where regression calculations cannot be resolved due to full inhibition extending beyond the highest doses tested. A therapeutic index (T.I.) was calculated as follows: [EC₅₀ for MetHb formation]/[EC₅₀ for parasite growth inhibition]. The change in T.I. was determined as follows: [T.I. without pyruvate]/[T.I. with pyruvate].