Table 1.
Results of the analysis of correlation between rs5743551 (TLR1), rs5743708 (TLR2), and rs4986790 (TLR4) polymorphisms and NET level (Me [Q1; Q3])
| Locus | Genotype | First blood sampling (n=38) | Second blood sampling (n=35) | ||
|---|---|---|---|---|---|
| n | NET level | n | NET level | ||
| rs5743551(TLR 1) | AA | 22 | 6.25 [4.40; 11.0] | 22 | 2.80 [0.33; 6.60] |
| AG | 12 | 5.25 [3.10; 13.20] | 9 | 2.0 [1.3; 6.4] | |
| GG | 4 | 6.40 [5.70; 7.95] | 4 | 2.75 [1.73; 4.50] | |
| p* (Kruskal–Wallis test) | 0.84 | 1.0 | |||
| rs5743708(TLR 2) | GG | 35 | 5.70 [3.95; 10.75] | 33 | 2.6 [0.6; 6.4] |
| AG | 3 | 11.0 [8.20; 11.95] | 2 | 4.0 [2.65; 5.35] | |
| AA | 0 | — | 0 | — | |
| p* (Mann–Whitney test) | 0.33 | 0.89 | |||
| rs4986790(TLR4) | AA | 30 | 6.8 [4.9; 11.3] | 29 | 3.1 [1.9; 6.7] |
| AG | 6 | 5.0 [3.5; 5.7] | 5 | 0 [0; 1.3] | |
| GG | 2 | 1.8 [1.2; 2.3] | 1 | 1.6 [1.2; 1.9] | |
| p* (Kruskal–Wallis test) | 0.027 | 0.09 | |||
* Statistical significance was calculated using 3×2 contingency tables. The second blood sampling was performed in 35 patients because of a lethal outcome in 3 people on the 5th–7th day.