Table 2.
Comparative analysis of the genotype/allele frequencies of rs5743551 (TLR1), rs5743708 (TLR2), and rs4986790 (TLR4) loci in groups with low and high levels of NETs at the first blood sampling (n (%))
| Locus | Genotype | NET level | p* | |
|---|---|---|---|---|
| Low (n=26) | High (n=12) | |||
| rs5743551 (TLR1) | AA | 15 | 7 | 1.0 |
| AG | 8 | 4 | ||
| GG | 3 | 1 | ||
| A allele | 38 (73) | 18 (75) | ||
| G allele | 14 (27) | 6 (25) | ||
| rs5743708 (TLR2) | GG | 25 | 10 | 0.233** |
| AG | 1 | 2 | ||
| AA | 0 | 0 | ||
| G allele | 51 (98) | 22 (92) | ||
| A allele | 1 (2) | 2 (8) | ||
| rs4986790 (TLR4) | AA | 18 | 12 | 0.123 |
| AG | 6 | 0 | ||
| GG | 2 | 0 | ||
| A allele | 42 (81) | 24 (100) | 0.026 | |
| G allele | 10 (19) | 0 | ||
| Dominant model (AA vs AG+GG) | 18/8 | 12/0 | 0.039 | |
* Statistical significance was calculated using Fisher’s test in contingency tables of 3×2 for genotypes and 2×2 for alleles; ** — a 2×2 contingency table for genotypes and alleles was used for the rs5743708 (TLR2) locus, due to the absence of one of the genotypes.