Table 4.
Comparative analysis of the genotype/allele frequencies for rs5743551 (TLR1), rs5743708 (TLR2), and rs4986790 (TLR4) polymorphisms in the groups of patients with different outcomes of pneumonia
| Locus | Genotype | Outcome | p* | OR (95% CI) | |
|---|---|---|---|---|---|
| Favorable (n=31) | Lethal (n=7) | ||||
| rs5743551 (TLR1) | AA | 22 | 0 | <0.0001** | — |
| AG | 9 | 3 | |||
| GG | 0 | 4 | |||
| А allele | 53 | 3 | <0.0001*** | 20.3 (4.3–135.0) | |
| G allele | 9 | 11 | |||
| rs5743708 (TLR2) | GG | 29 | 6 | 0.47 | — |
| AG | 2 | 1 | |||
| AA | 0 | 0 | |||
| rs4986790 (TLR4) | AA | 26 | 4 | 0.16 | — |
| AG | 4 | 2 | |||
| GG | 1 | 1 | |||
| A allele | 56 | 10 | 0.08 | 3.65 (0.64–18.90) | |
| G allele | 6 | 4 | |||
* Statistical significance was calculated using Fisher’s test in contingency tables of 3×2 for genotypes and 2×2 for alleles; ** — 1.74·10–5; *** — 7.06·10–6.