TABLE 4.
Unstandardized regression coefficients and model fit indices by research question for all models.
|
Intercept
|
Slope
|
Model fit indices
|
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| β | SE | p | β | SE | p | H0 value | Free parameters | −2LL | AIC | BIC | |
| Research Question 1 | |||||||||||
|
| |||||||||||
| FRS (n = 524) | –0.135 | 0.048 | 0.005 | –0.007 | 0.002 | 0.003 | –700.892 | 12 | 1,401.784 | 1,425.784 | 1,476.922 |
| Sex | 0.203 | 0.106 | 0.055 | 0.013 | 0.005 | 0.008 | |||||
| LRS (n = 595) | –0.197 | 0.035 | 0.000 | –0.009 | 0.002 | 0.000 | –805.219 | 12 | 1,610.438 | 1,634.439 | 1,687.102 |
| Sex | 0.146 | 0.092 | 0.112 | 0.009 | 0.004 | 0.047 | |||||
| M-CRS (n = 520) | –0.161 | 0.031 | 0.000 | –0.007 | 0.001 | 0.001 | –687.957 | 12 | 1,363.914 | 1,387.914 | 1,438.960 |
| Sex | 0.275 | 0.103 | 0.008 | 0.015 | 0.005 | 0.001 | |||||
|
| |||||||||||
| Research Question 2 | |||||||||||
|
| |||||||||||
| APOE ε4− | |||||||||||
| FRS (n = 391) | –0.140 | 0.052 | 0.007 | –0.007 | 0.002 | 0.002 | –689.055 | 24 | 1,378.110 | 1,426.110 | 1,528.386 |
| Sex | 0.273 | 0.123 | 0.026 | 0.017 | 0.005 | 0.002 | |||||
| LRS (n = 447) | –0.210 | 0.039 | 0.000 | –0.009 | 0.002 | 0.000 | –790.016 | 24 | 1,580.032 | 1,628.031 | 1,733.357 |
| Sex | 0.217 | 0.101 | 0.032 | 0.012 | 0.005 | 0.014 | |||||
| M-CRS (n = 387) | –0.168 | 0.033 | 0.000 | –0.007 | 0.002 | 0.000 | –668.758 | 24 | 1,337.516 | 1,385.515 | 1,487.607 |
| Sex | 0.357 | 0.114 | 0.002 | 0.020 | 0.005 | 0.000 | |||||
| APOE ε4+ | |||||||||||
| FRS (n = 133) | –0.149 | 0.124 | 0.230 | –0.006 | 0.006 | 0.309 | –689.055 | 24 | 1,378.110 | 1,426.110 | 1,528.386 |
| Sex | –0.021 | 0.255 | 0.935 | 0.001 | 0.012 | 0.940 | |||||
| LRS (n = 148) | –0.165 | 0.083 | 0.048 | –0.008 | 0.004 | 0.035 | –790.016 | 24 | 1,580.032 | 1,628.031 | 1,733.357 |
| Sex | –0.083 | 0.220 | 0.707 | –0.001 | 0.010 | 0.902 | |||||
| M-CRS (n = 133) | –0.157 | 0.080 | 0.048 | –0.007 | 0.004 | 0.053 | –668.758 | 24 | 1,337.516 | 1,385.515 | 1,487.607 |
| Sex | 0.024 | 0.256 | 0.925 | 0.003 | 0.012 | 0.797 | |||||
|
| |||||||||||
| Research Question 3 | |||||||||||
|
| |||||||||||
| Low AD-GRS in APOE ε4− group | |||||||||||
| FRS (n = 66) | 0.089 | 0.135 | 0.510 | 0.001 | 0.005 | 0.796 | –460.739 | 24 | 921.478 | 969.479 | 1,064.543 |
| Sex | –0.035 | 0.350 | 0.920 | 0.009 | 0.014 | 0.533 | |||||
| LRS (n = 78) | –0.269 | 0.108 | 0.013 | –0.015 | 0.005 | 0.006 | –543.272 | 24 | 1,086.544 | 1,134.544 | 1,232.844 |
| Sex | –0.080 | 0.304 | 0.792 | –0.001 | 0.013 | 0.950 | |||||
| M-CRS (n = 66) | –0.110 | 0.088 | 0.209 | –0.006 | 0.004 | 0.082 | –443.038 | 24 | 886.076 | 934.077 | 1,028.892 |
| Sex | 0.169 | 0.333 | 0.612 | 0.014 | 0.013 | 0.285 | |||||
| High AD-GRS in APOE ε4− group | |||||||||||
| FRS (n = 322) | –0.204 | 0.056 | 0.000 | –0.010 | 0.003 | 0.000 | –460.739 | 24 | 921.478 | 969.479 | 1,064.543 |
| Sex | 0.333 | 0.130 | 0.010 | 0.018 | 0.006 | 0.004 | |||||
| LRS (n = 366) | –0.191 | 0.043 | 0.000 | –0.007 | 0.002 | 0.002 | –543.272 | 24 | 1,086.544 | 1,134.544 | 1,232.844 |
| Sex | 0.274 | 0.112 | 0.015 | 0.014 | 0.006 | 0.014 | |||||
| M-CRS (n = 318) | –0.179 | 0.036 | 0.000 | –0.007 | 0.002 | 0.000 | –443.038 | 24 | 886.076 | 934.077 | 1,028.892 |
| Sex | 0.391 | 0.123 | 0.000 | 0.019 | 0.006 | 0.002 | |||||
| Low AD-GRS in APOE ε4+ group | |||||||||||
| FRS (n = 15) | –0.437 | 0.397 | 0.270 | –0.011 | 0.035 | 0.761 | –197.268 | 20 | 394.536 | 434.536 | 492.343 |
| Sex | Not a good model fit | ||||||||||
| LRS (n = 17) | –0.317 | 0.497 | 0.523 | –0.016 | 0.018 | 0.370 | –221.547 | 24 | 443.094 | 491.094 | 563.027 |
| Sex | –0.915 | 1.022 | 0.371 | –0.022 | 0.052 | 0.677 | |||||
| M-CRS (n = 15) | –0.341 | 0.224 | 0.146 | –0.005 | 0.016 | 0.775 | –188.715 | 24 | 377.430 | 425.429 | 494.798 |
| Sex | –0.771 | 0.773 | 0.318 | –0.042 | 0.036 | 0.245 | |||||
| High AD-GRS in APOE ε4+ group | |||||||||||
| FRS (n = 118) | –0.092 | 0.126 | 0.466 | –0.005 | 0.006 | 0.335 | –197.268 | 20 | 394.536 | 434.536 | 492.343 |
| Sex | Not a good model fit | ||||||||||
| LRS (n = 131) | –0.164 | 0.094 | 0.080 | –0.008 | 0.004 | 0.066 | –221.547 | 24 | 443.094 | 491.094 | 563.027 |
| Sex | 0.022 | 0.242 | 0.927 | 0.002 | 0.012 | 0.884 | |||||
| M-CRS (n = 118) | –0.127 | 0.089 | 0.154 | –0.006 | 0.004 | 0.110 | –188.715 | 24 | 377.430 | 425.429 | 494.798 |
| Sex | 0.130 | 0.284 | 0.648 | 0.007 | 0.014 | 0.616 | |||||
SE = standard error; H0 = log likelihood; −2LL = −2 log likelihood; AIC = Akaike Information Criteria; BIC = Bayesian Information Criteria. FRS = functional-health risk score; LRS = lifestyle-reserve risk score; M-CRS = Modifiable-Composite Risk Score (FRS + LRS). Sex was included as a covariate in all the models.