Table 3.
AP propertiesa
| AP properties | Control (hrGFP) (n = 8) | shSLK-hrGFP (n = 12) |
|---|---|---|
| Peak potential | 35.1 ± 1.7 | 32.3 ± 1.8 |
| Peak depolarization rate (V/s) | 366 ± 25 | 319 ± 20** |
| Peak repolarization rate (V/s) | −70.3 ± 2.7 | −58.4 ± 2.8 |
| Threshold (mV) | −50.3 ± 1.0 | −46.5 ± 1.6 |
| Duration at half-amplitude (ms) | 1.1 ± 0.04 | 1.25 ± 0.06 |
| Fast afterhyperpolarization amplitude (mV) | 5.9 ± 1.1 | 6.1 ± 1.6 |
aAPs were recorded from cells expressing control (hrGFP) or shSLK (shSLK-hrGFP) encoding plasmids that were introduced by IUE at E14. n = 8 control (hrGFP) and n = 12 shSLK-hrGFP neurons; two-way ANOVA (interaction: p(F=2.497; df=5, 108) = 0.0351; AP properties: p(F=516; df=5, 108) < 0.0001; condition: p(F=1.086; df=1, 108) = 0.2997); Sidak's multiple-comparisons test, **p < 0.01, for comparison between indicated value and respective control value (in detail: peak potential: p(t=0.2118, df=108) > 0.9999; peak depolarization rate: p(t=3.555, df=108) = 0.0034; peak repolarization rate: p(t=0.9, df=108) = 0.9376; threshold: p(t=0.2874, df=108) = 0.9999; duration at half amplitude: p(t=0.01,134, df=108) > 0.9999; fast afterhyperpolarization amplitude: p(t=0.01513, df=108) > 0.9999).