Table 4.
Dominant and recessive models for the selected SNPs
| Gene (SNP) | Genetic model | Cases (n=141) | Controls (n=107) | OR [95% CI] | χ 2 | P | |
|---|---|---|---|---|---|---|---|
| CRYAA (rs378805) | Dominant | AA + AG | 36 (0.255) | 9 (0.084) | 3.73 [1.71, 8.15] | 12.01 | 0.001 |
| GG | 105 (0.745) | 98 (0.916) | - | - | - | ||
| Recessive | AA | 2 (0.014) | 0 (0.000) | 3.85 [0.18, 81.10] | 1.53 | 0.220 | |
| AG + GG | 139 (0.986) | 107 (1.000) | - | - | - | ||
| CRYAB (rs2070894) | Dominant | AA + AG | 77 (0.546) | 76 (0.710) | 0.49 [0.29, 0.84] | 6.94 | 0.008 |
| GG | 64 (0.454) | 31 (0.290) | - | - | - | ||
| Recessive | AA | 3 (0.021) | 1 (0.009) | 2.3 [0.24, 22.47] | 0.55 | 0.460 | |
| AG + GG | 138 (0.979) | 106 (0.991) | - | - | - | ||
| CRYBA4 (rs2071861) | Dominant | GG + AA | 85 (0.603) | 58 (0.542) | 1.28 [0.77, 1.13] | 0.92 | 0.340 |
| AA | 56 (0.397) | 49 (0.458) | - | - | - | ||
| Recessive | GG | 30 (0.213) | 20 (0.187) | 1.18 [0.63, 2.21] | 0.25 | 0.620 | |
| AG + AA | 111 (0.787) | 87 (0.813) | - | - | - | ||
| CRYBB2 (rs5752083) | Dominant | AA + AC | 122 (0.865) | 103 (0.963) | 0.25 [0.08, 0.76] | 6.85 | 0.009 |
| CC | 19 (0.135) | 4 (0.037) | - | - | - | ||
| Recessive | AA | 20 (0.142) | 7 (0.065) | 2.36 [0.96, 5.81] | 3.66 | 0.060 | |
| AC + CC | 121 (0.858) | 100 (0.935) | - | - | - | ||
| CRYBB2 (rs5996863) | Dominant | TT + CT | 137 (0.972) | 102 (0.953) | 1.68 [0.44, 6.41] | 0.59 | 0.440 |
| CC | 4 (0.028) | 5 (0.047) | - | - | - | ||
| Recessive | TT | 25 (0.177) | 12 (0.112) | 1.71 [0.81, 3.57] | 2.03 | 0.150 | |
| CT + CC | 116 (0.823) | 95 (0.888) | - | - | - | ||
SNP: Single nucleotide polymorphism, OR: Odds ratio, CI: Confidence interval