Table 1.
Patient and tumor characteristics in 2,752 patients aged ≥15 years and living in the Veneto Region who were diagnosed and/or treated for Melanoma of the skin between 1998-2014 at the Veneto Institute of Oncology and at the University Hospital of Padua (Italy): comparison between age classes (15-25 years, 26-39 years, 40 years or older).
| Adolescents and youth (15-25 years) | Young adults (26-39 years) | Adults (40 years or older) | p-value | |
|---|---|---|---|---|
| N | 76 | 626 | 2050 | – |
| Sex: | <0.0001 | |||
| Female | 43 (56.6) | 389 (62.1) | 1010 (49.3) | |
| Male | 33 (43.4) | 237 (37.9) | 1040 (50.7) | |
| Primary site: | 0.0003 | |||
| Acral | 2 (2.6) | 16 (2.6) | 137 (6.7) | |
| Head/neck | 2 (2.6) | 32 (5.1) | 150 (7.3) | |
| Upper limb | 7 (9.2) | 89 (14.2) | 295 (14.4) | |
| Trunk | 47 (61.8) | 318 (50.8) | 947 (46.2) | |
| Lower limb | 18 (23.6) | 171 (27.3) | 521 (25.4) | |
| Breslow ab | 0.63 (0.39-1.20) | 0.57 (0.35-1.09) | 0.75 (0.39-1.90) | <0.0001 |
| Ulceration: | 0.04 | |||
| Absent | 56 (73.7) | 508 (81.1) | 1561 (76.1) | |
| Present | 16 (21.0) | 100 (16.0) | 435 (21.2) | |
| Unknown | 4 (5.3) | 18 (2.9) | 54 (2.6) | |
| Mitotic rate(per mm2) ac | 1 (0-2) | 1 (0-2) | 2 (0-4) | 0.02 |
| pTNM stage: | 0.0005 | |||
| I | 55 (72.4) | 470 (75.1) | 1387 (67.7) | |
| II | 10 (13.1) | 64 (10.2) | 337 (16.4) | |
| III | 11 (14.5) | 90 (14.4) | 326 (15.9) | |
| IV | 0 (0.0) | 2 (0.3) | 0 (0.0) | |
| pT: | <0.0001 | |||
| 1a-b, 2a-b | 64 (84.2) | 534 (85.3) | 1562 (76.2) | |
| 3a-b, 4a-b | 12 (15.8) | 92 (14.7) | 488 (23.8) | |
| pN: | 0.63 | |||
| 0 | 65 (85.5) | 536 (85.6) | 1724 (84.1) | |
| 1-3 | 11 (14.5) | 90 (14.4) | 326 (15.9) | |
| pM: | 624 (99.7) | 0.11 | ||
| 0 | 76 (100.0) | 2 (0.3) | 2050 (100.0) | |
| 1a-d | 0 (0.0) | 0 (0.0) | ||
| Subtype: d | <0.0001 | |||
| ALM* | 1 (1.5) | 7 (.2) | 72 (3.5) | |
| LMM* | 0 (0.0) | 2 (0.3) | 37 (1.8) | |
| NM* | 9 (12.7) | 74 (12.9) | 335 (16.3) | |
| SSM* | 53 (74.6) | 469 (81.6) | 1541 (75.2) | |
| Other** | 8 (11.2) | 23 (4.0) | 65 (3.2) |
Data expressed as n (%) or a median (IQR). Data not available in b70, c15, d56 patients. *ALM, Acral lentiginous melanoma; LMM, lentigo maligna melanoma; NM, nodular melanoma; SSM, superficial spreading melanoma. **Spitzoid Melanoma, Nevoid melanoma, pagetoid melanoma, polypoid melanoma, desmoplastic melanoma, minimal deviation melanoma and neurotropic melanoma.
The bold values are statistically significant.