Table 2.

Baseline and exercise haemodynamics, metabolism, and ventricular function

	Baseline		20 W exercise		Peak exercise		P-valueª
	Control	HFpEF	Control	HFpEF	Control	HFpEF
HR (bpm)	68 ± 13	67 ± 10	91 ± 14	88 ± 14	121 ± 18	97 ± 15	<0.001
SBP (mmHg)	139 ± 24	149 ± 21	167 ± 29	175 ± 26	184 ± 25	185 ± 30	0.2
MBP (mmHg)	91 ± 13	96 ± 13	106 ± 15	108 ± 15	111 ± 12	111 ± 15	0.3
Central haemodynamics
RAP (mmHg)	4 ± 2	10 ± 4*	8 ± 3	21 ± 5*	8 ± 4	22 ± 6*	<0.001
PASP (mmHg)	27 ± 6	41 ± 12*	37 ± 10	66 ± 12*	41 ± 9	70 ± 13*	<0.001
mPAP (mmHg)	16 ± 4	27 ± 8*	25 ± 7	47 ± 10*	27 ± 6	48 ± 8*	<0.001
PCWP (mmHg)	7 ± 3	17 ± 6*	13 ± 5	31 ± 5*	14 ± 5	34 ± 6*	<0.001
PVR (WU)	1.9 ± 0.8	2.0 ± 1.2	1.5 ± 0.7	2.3 ± 1.2†	1.3 ± 0.6	2.1 ± 1.2	0.016
PAC (mL/mmHg)	4.4 ± 1.5	3.6 ± 1.3‡	4.8 ± 2.2	2.6 ± 1.2*	4.3 ± 1.6	2.6 ± 1.4*	<0.001
Integrated function
VO2 (mL/min)	211 ± 61	242 ± 54‡	640 ± 99	629 ± 130	1162 ± 389	809 ± 220*	<0.001
VO2 (mL/min/kg)	2.60 ± 0.49	2.49 ± 0.54	8.13 ± 1.62	6.54 ± 1.60†	14.4 ± 4.1	8.3 ± 2.1*	<0.001
Sa O2 (mL/dL)	16.8 ± 1.7	15.0 ± 1.9†	17.2 ± 1.7	15.5 ± 2.0†	17.8 ± 1.7	15.9 ± 2.0†	0.9
PA O2 (mL/dL)	12.6 ± 1.7	10.2 ± 1.6*	9.4 ± 2.2	6.1 ± 1.8*	7.9 ± 2.4	5.6 ± 1.9*	<0.001
AVO2diff (mL/dL)	4.1 ± 0.9	4.8 ± 0.9†	7.9 ± 1.4	9.3 ± 1.9†	9.9 ± 1.7	10.4 ± 2.3	0.002
CO (L/min)	5.2 ± 1.8	5.1 ± 1.2	8.2 ± 1.8	6.8 ± 2.0†	11.8 ± 3.9	8.1 ± 2.8*	<0.001
SV (mL)	77 ± 23	77 ± 19	93 ± 24	78 ± 21†	98 ± 28	83 ± 27‡	0.007
Ventricular mechanics
RV e′ (cm/s)	11 ± 5	12 ± 9	13 ± 5	11 ± 5	19 ± 9	12 ± 6	0.010
RV s′ (cm/s)	12 ± 3	11 ± 3	13 ± 4	10 ± 3	14 ± 4	11 ± 3	0.044
LV e′ (cm/s)	8.5 ± 2.1	6.9 ± 2.0†	10 ± 3	7 ± 2	13 ± 5	8 ± 3*	<0.001
LV s′ (cm/s)	7.5 ± 1.9	6.4 ± 1.5†	8 ± 2	7 ± 2‡	11 ± 3	8 ± 2†	0.025

ªTwo-way RMANOVA for comparing the exercise-dependent change in each variable between groups.

*P<0.001 vs. control.

^†P<0.01 vs. control.

^‡P<0.05 vs. control for single time point comparisons.