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. 2021 Sep 16;15:745178. doi: 10.3389/fncel.2021.745178

Figure 2.

Figure 2

Mechanical neuropathic allodynia in GFAP-DOR-KO mice. (A) Mechanical sensitivity thresholds in GFAP-DOR-KO and DOR-flox mice. GFAP-DOR-KO mice showed overall higher nociceptive mechanical thresholds. There was no genotype difference when evaluated in separated sexes (Two-way ANOVA followed by Sidak’s multiple comparison tests). *, p < 0.05 GFAP-DOR-KO vs. DOR-flox. (B) Partial sciatic nerve ligation (pSNL) induced comparable mechanical allodynia at the ipsilateral side in GFAP-DOR-KO and DOR-flox mice of both sexes. (C) pSNL induced a mild allodynia at the contralateral side in both GFAP-DOR-KO and DOR-flox mice in the two sexes. n = 16 DOR-flox females, n = 11 GFAP-DOR-KO females, n = 16 DOR-flox males, n = 12 GFAP-DOR-KO males. Two-way repeated measures ANOVA followed by Sidak’s multiple comparison test. Data are expressed as mean ± SEM. See also Supplementary Table 2 for statistics.