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. 2021 Sep 16;15:745178. doi: 10.3389/fncel.2021.745178

Figure 4.

Figure 4

Cold neuropathic allodynia was attenuated in GFAP-DOR-KO mice. (A) Baseline paw responses on the cold plate in GFAP-DOR-KO and DOR-flox mice. GFAP-DOR-KO mice reacted comparably to DOR-flox control mice (Two-way ANOVA). (B) Paw responses at the ipsilateral side on the cold plate following pSNL. Cold allodynia was abolished in DOR-GFAP-KO females, with genotype differences on individual days 11 and 14. Cold allodynia was reduced in GFAP-DOR-KO males with a genotype difference on day 11 time-point. (C) The comparison of cold allodynia in DOR-flox females and males indicated no sex difference. (D) There was a modest cold allodynia at the contralateral side in males but not females, which did not reach significance at any individual time points. n = 16 DOR-flox females, n = 10 GFAP-DOR-KO females, n = 17 DOR-flox males, n = 14 GFAP-DOR-KO males. Two-way repeated measures ANOVA followed by Sidak’s multiple comparison test. Data are expressed as mean ± SEM. See also Supplementary Table 4 for statistics.