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. 2017 Feb 3;96(2):352–365. doi: 10.1095/biolreprod.116.143735

Figure 1.

Figure 1.

Model of SNARE function in membrane fusion leading to completion of the acrosome reacion. (A) Acrosome intact mouse sperm with plasma membrane (PM), outer acrosomal membrane (OAM), and inner acrosomal membrane (IAM) immediately prior to membrane interaction. Syntaxin 2 (STX2) and SNAP25 are present on the plasma membrane, while VAMP2 is apposed to them on the outer acrosomal membrane. (B) Trans-SNARE complex formation is promoting interaction of the plasma membrane and outer acrosomal membrane. (C) Membrane fusion is leading to formation of fusion pores, leading to release of acrosomal contents. (D) Sperm after the release of the plasma and outer acrosomal membranes.