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. 2021 Sep 30;17(9):e1009950. doi: 10.1371/journal.ppat.1009950

Fig 8. Model summarizing the regulatory role of miR-24 in HSV1 induced STING signaling.

Fig 8

The model depicts the regulation of STING protein levels by HSV1 induced miR-24 expression which inhibits STING signaling and promotes viral replication. HSV1 infection activates MAPKs which enhance the expression of AOPEP mRNA and miR-23b, miR-27b, miR-24 leading to miR-24 accumulation and targeting of STING signaling. This acts as an immune evasion strategy adopted by the virus to augment its own replication.