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. 2021 Sep 20;17(9):e1009424. doi: 10.1371/journal.pcbi.1009424

Fig 5. Disruption of network oscillations diminishes spike timing relationships between neurons.

Fig 5

A-E) MODEL DATA: A-D) Simulated raster-plots; NREM-like network dynamics for the progressively larger disruption of inhibitory firing. E) Weighted sum of differences in model asymmetry significance distributions after consolidation (unperturbed model in (D) minus model without inhibition in (A)). F) EXPERIMENTAL DATA: Difference in experimental asymmetry significance distributions, shown as the black trace, for CA1 recordings for mice expressing the inhibitory DREADD hM4Di in PV+ interneurons, treated with either DMSO (analogous to the full model network) or CNO (analogous to reduced network inhibition); compare to randomized spike times used to estimate significance of these values, shown in blue. Error bars denote SEM of repeated simulations (E) or SEM across all experimental animals (F). * p < 0.05; ** p < 0.01 using a two-sided t-test.