Table 1. Binding affinities of PI polyamides for ALK mutation (F1174L) or ALK wild-type (WT) oligonucleotides.

PIP	ALK sequence	KD [10−8 M]a	ka [104 M-1S-1]b	kd [10−3 S-1]c	Specificity
CCC-003-Dp	F1174L	6.37 ± 0.41	1.97 ± 0.05	1.26 ± 0.02	9.14
Mismatch-Dp	F1174L	N.D.	N.D.	N.D.	N.D.
CCC-003-Dp	WT	58.20 ± 1.62	0.29 ± 0.021	1.71 ± 0.03	1.00
Mismatch-Dp	WT	N.D.	N.D.	N.D.	N.D.

^a)Equilibrium dissociation constant

^b)Association rate constant

^c)Dissociation rate constant

N.D., not detected.