Table 4. MIC (μM) and Percentage of Hemolysis of hECP30 (1) and Analogsa.
| peptide | E. coli | A. baumannii | Pseudomonas sp. | S. enterica | S. flexneri | hemolysis % (250 μM peptide) | MRC-5 cytotoxicity (IC50, μM) |
|---|---|---|---|---|---|---|---|
| 1 | 1.56 | 1.56 | 1.56 | 12.5 | 3.13 | 44 ± 4 | 23 ± 4 |
| 2 | 6.25 | 6.25 | 6.25 | 25 | 12.5 | 10 ± 2 | 113 ± 8 |
| 3 | 6.25 | 50 | 3.13 | 50 | 6.25 | 14 ± 6 | 182 ± 9 |
| 4 | 6.25 | 12.5 | 3.13 | 25 | 3.13 | 43 ± 1 | 7.6 ± 0.7 |
| 5 | 25 | >100 | 25 | >100 | 50 | 11 ± 4 | > 300 |
| 6 | 3.13 | 12.5 | 1.56 | 50 | 50 | 1.1 ± 0.9 | 230 ± 40 |
| 7 | 3.13 | 6.25 | 1.56 | 25 | 6.25 | 3.6 ± 0.7 | 170 ± 20 |
| LL-37 | 1.56 | 6.25 | 1.56 | 12.5 | 12.5 | 58 ± 7 | 64 ± 2 |
a
LL-37 included for comparison.