Table 3.
Clinical and Laboratory Characteristics in Patients With CIS by Tertiles of LnRHI
| LnRHI | ||||
|---|---|---|---|---|
| Low LnRHI | Medium LnRHI | High LnRHI | P Value | |
| Age, median (IQR), y | 43.8 (36.1–47.1) | 40.6 (36.1–46.2) | 40.2 (29.6–44.1) | 0.157 |
| Men | 33 (67.3) | 32 (56.1) | 11 (36.7) | 0.009 |
| Low level of education | 28 (57.1) | 25 (43.9) | 16 (53.3) | 0.590 |
| Hypertension | 15 (30.6) | 23 (40.4) | 3 (10.0) | 0.019 |
| Dyslipidemia | 34 (69.4) | 27 (47.4) | 14 (46.7) | 0.029 |
| Diabetes mellitus | 3 (6.1) | 0 (0) | 1 (3.3) | 0.331 |
| Current smoking | 17 (34.7) | 21 (36.8) | 4 (13.3) | 0.098 |
| Heavy alcohol use | 13 (26.5) | 15 (26.3) | 5 (16.7) | 0.367 |
| Physical activity, 1000 MET per wk | 3.14 (1.1–5.4) | 3.31 (1.7–4.1) | 3.59 (1.9–7.5) | 0.549 |
| Obesity | 35 (71.4) | 34 (59.6) | 7 (23.3) | <0.001 |
| Diet score (10) | 25 (21–29) | 22 (20–28) | 26 (24–31) | 0.028 |
| Prestroke medication | ||||
| Antihypertensive | 3 (6.1) | 12 (21.1) | 0 (0) | 0.742 |
| Statin | 3 (6.1) | 1 (1.8) | 0 (0) | 0.099 |
| Medication at study visit | ||||
| Antihypertensive | 25 (51.0) | 32 (56.1) | 7 (23.3) | 0.039 |
| Statin | 40 (81.6) | 48 (84.2) | 23 (76.7) | 0.660 |
| Admission laboratory assessment | ||||
| CRP, mg/L | 1.5 (1.5–4.5) | 1.5 (1.5–2.3) | 1.5 (1.5–1.5) | 0.093 |
| eGFR, mL/min per 1.73 m2 | 103 (17) | 102 (15) | 101 (18) | 0.343 |
| LDL‐C, mmol/L | 3.1 (1.0) | 3.1 (1.0) | 3.1 (0.9) | 0.997 |
| HDL‐C, mmol/L | 1.2 (0.4) | 1.3 (0.4) | 1.5 (0.4) | 0.027 |
| Total cholesterol/HDL‐C ratio | 4.1 (1.3) | 3.8 (1.3) | 3.4 (0.9) | 0.032 |
| Triglycerides, mmol/L | 1.6 (1.8) | 1.4 (0.7) | 1.1 (0.5) | 0.138 |
| HbA1c, mmol/mol | 36 (32–38) | 34 (33–37) | 34 (32–35) | 0.246 |
| Study visit laboratory assessment | ||||
| hs‐CRP, mg/L | 1.14 (0.56–4.20) | 0.77 (0.41–3.16) | 0.98 (0.37–1.69) | 0.387 |
| eGFR, mL/min per 1.73 m2 | 65 (63–70) | 67 (63–71) | 65 (62–71) | 0.782 |
| LDL‐C, mmol/L | 2.3 (0.7) | 2.2 (0.7) | 2.4 (0.7) | 0.650 |
| HDL C, mmol/L | 1.1 (0.3) | 1.2 (0.3) | 1.2 (0.3) | 0.047 |
| Total cholesterol/HDL‐C ratio | 3.6 (0.8) | 3.4 (0.8) | 3.3 (0.7) | 0.115 |
| Triglycerides, mmol/L | 1.7 (1.0) | 1.4 (0.6) | 1.3 (0.7) | 0.126 |
| GA (1), nmol/mL | 87.5 (27.7) | 88.9 (26.9) | 91.5 (23.2) | 0.913 |
Data are expressed as number (percentage), median (interquartile range), or mean (SD).
CIS indicates cryptogenic ischemic stroke; CRP, C‐reactive protein; eGFR, estimated glomerular filtration rate; GA, glycated albumin; HbA1c, glycated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; hs‐CRP, high‐sensitivity C‐reactive protein; IQR, interquartile range; LDL‐C, low‐density lipoprotein cholesterol; LnRHI, natural logarithm of reactive hyperemia index; MET, metabolic equivalent; and NA, not applicable.