Table 4.
Conditional Logistic Regression on the Association Between Endothelial Function (Tertiles of LnRHI) and CIS Stratified By Sex and Age (Dichotomized At Median)
| All Participants | Prevalence in Patients | Model 1: Adjusted for Demographics and Vascular Risk Factors* | Model 2: Adjusted for Demographics, Vascular Risk Factors, and Admission Total Cholesterol/HDL‐C Ratio† | Model 3: Adjusted for Demographics, Vascular Risk Factors, and Study Visit Total Cholesterol/HDL‐C Ratioǂ | Model 4: Adjusted for Demographics, Vascular Risk Factors, and Study Visit Total Cholesterol/HDL‐C Ratio and GA |
|---|---|---|---|---|---|
| No. (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Low LnRHI | 49 (36.0) | 1.38 (0.74–2.56) | 1.39 (0.75–2.56) | 1.22 (0.64–2.33) | 1.08 (0.54–2.15) |
| Medium LnRHI | 57 (41.9) | 1.54 (0.76–3.12) | 1.67 (0.82–3.35) | 1.36 (0.65–2.84) | 1.33 (0.61–2.87) |
| High LnRHI | 30 (22.1) | Reference | Reference | Reference | Reference |
| Women | |||||
| Low LnRHI | 16 (26.7) | 0.47 (0.18–1.28) | 0.48 (0.18–1.29) | 0.49 (0.17–1.40) | 0.34 (0.10–1.17) |
| Medium LnRHI | 22 (36.7) | 1.05 (0.33–3.34) | 0.95 (0.29–3.12) | 0.95 (0.29–3.19) | 1.06 (0.30–3.78) |
| High LnRHI | 22 (36.7) | Reference | Reference | Reference | Reference |
| Men | |||||
| Low LnRHI | 33 (43.4) | 3.50 (1.22–10.07) | 3.52 (1.24–10.03) | 2.89 (0.98–8.54) | 2.78 (0.82–9.44) |
| Medium LnRHI | 32 (42.1) | 1.97 (0.68–5.73) | 2.29 (0.81–6.52) | 1.88 (0.63–5.61) | 1.86 (0.58–6.02) |
| High LnRHI | 11 (14.5) | Reference | Reference | Reference | Reference |
| Younger participants | |||||
| Low LnRHI | 19 (27.5) | 0.69 (0.27–1.81) | 0.68 (0.27–1.72) | 0.54 (0.20–1.50) | 0.50 (0.17–1.52) |
| Medium LnRHI | 21 (30.4) | 0.98 (0.36–2.67) | 0.90 (0.32–2.55) | 0.91 (0.33–2.56) | 0.99 (0.35–2.82) |
| High LnRHI | 29 (42.0) | Reference | Reference | Reference | Reference |
| Older participants | |||||
| Low LnRHI | 41 (61.2) | 5.78 (1.52–21.95) | 4.16 (1.32–13.14) | 3.72 (1.02–13.62) | 5.74 (1.04–31.63) |
| Medium LnRHI | 18 (26.9) | 2.62 (0.63–10.83) | 1.94 (0.54–6.90) | 2.01 (0.03–7.51) | 2.70 (0.52–14.12) |
| High LnRHI | 8 (11.9) | Reference | Reference | Reference | Reference |
CIS indicates cryptogenic ischemic stroke; GA, glycated albumin; LnRHI, natural logarithm of reactive hyperemia index; and OR, odds ratio.
Vascular risk factors included hypertension, dyslipidemia, current smoking, heavy drinking, obesity, diet score, and diabetes mellitus in men and older patients.
Vascular risk factors included hypertension, current smoking, heavy drinking, obesity, diet score, and diabetes mellitus in men and older patients. From patients, total cholesterol/high‐density lipoprotein cholesterol (HDL‐C) ratio was obtained on admission; from controls, total cholesterol/HDL‐C ratio was obtained at study visit.
Vascular risk factors included hypertension, current smoking, heavy drinking, obesity, diet score, and diabetes mellitus in men and older patients. Total cholesterol/HDL‐C ratio was obtained at study visit.