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. 2021 Jul 14;10(14):e016543. doi: 10.1161/JAHA.120.016543

Figure 6. Effects of enalapril and candesartan on the expression of renin‐angiotensin system components in the renal cortex of high‐fructose diet (HFr)–fed Dahl salt‐sensitive (DS) rats.

Figure 6

The HFr‐fed DS rats were treated with enalapril (HFr‐Ena; 10 mg/kg per day) or candesartan (HFr‐Can; 1 mg/kg per day) for 12 weeks. Angiotensinogen (AGT) (A), renin (B), angiotensin‐converting enzyme (ACE) (C), (pro)renin receptor ([P]RR) (E), angiotensin II type 1 receptor (AT1R) (F), angiotensin II type 2 receptor (AT2R) (G) protein expressions and ACE activity (D) were compared among the control diet (Con) (n=6), HFr (n=6), HFr‐Ena (n=6), and HFr‐Can (n=6) groups. Top panels in A through C and E through G depict representative immunoblots from the different groups. The intensities of each specific protein band were normalized to that of β‐actin, and the mean intensities of the values for the Con group. Data are presented as mean±SEM. *P<0.05, **P<0.01 compared with the Con group; # P<0.05, ## P<0.01 compared with the HFr group.