Table 1.

Impacts of High‐Fructose Intake on Body Weight and Plasma Parameters in DR Rats and DS Rats

Variable	Con‐DR Rats (n=8)	HFr‐DR Rats (n=8)	Con‐DS Rats (n=8)	HFr‐DS Rats (n=8)	Diet	Strain	Interaction
Body weight, g	475±9	468±8	402±6†	397±6§	NS	<0.05	NS
HOMA‐IR	0.30±0.02	0.43±0.03†	0.55±0.03†	0.68±0.04†,§,‖	<0.05	<0.05	NS
Triglyceride, mg/dL	178±13	775±32†	272±27*	831±45†,¶	<0.05	<0.05	NS
Total cholesterol, mg/dL	82±2	91±1†	77±3	102±3†,§,¶	<0.05	NS	<0.05
Free fatty acid, mEq/L	399±37	581±51*	259±32*	377±39‡	<0.05	<0.05	NS
Glucose, mg/dL	161±2	179±3†	172±8	201±8†,‡,‖	<0.05	<0.05	NS
Creatinine, mg/dL	0.35±0.01	0.34±0.01	0.34±0.02	0.24±0.02†,§,¶	<0.05	<0.05	<0.05
Uric acid, mg/dL	1.66±0.03	2.02±0.04†	1.64±0.04	2.01±0.07†,¶	<0.05	NS	NS
CCr, mL/min	3.53±0.12	3.28±0.10	3.07±0.14*	4.17±0.34‡,‖	<0.05	NS	<0.05
Renin activity, ng/mL per h	6.2±0.6	9.2±0.7*	5.2±0.8	2.9±0.4†,§,‖	NS	<0.05	<0.05

Data are presented as mean±SEM. CCr indicates creatinine clearance; Con‐DR, control diet–fed DR; Con‐DS, control diet–fed DS; DR, Dahl salt resistant; DS, Dahl salt sensitive; HFr‐DR, high‐fructose–fed DR; HFr‐DS, high‐fructose–fed DS; HOMA‐IR, homeostasis model assessment for insulin resistance; and NS, no significance.

^*P<0.05, ^†P<0.01 compared with the Con‐DR group.

^‡P<0.05, ^§P<0.01 compared with the HFr‐DR group.

^‖P<0.05, ^¶P<0.01 compared with the Con‐DS group.