Table 2.

Effects of Enalapril and Candesartan on Body Weight and Plasma Parameters in High‐Fructose–Fed DS Rats

Variable	Con‐DS Rats (n=6)	HFr‐DS Rats (n=6)	HFr‐Ena DS Rats (n=6)	HFr‐Can DS Rats (n=6)
Body weight, g	398±6	397±6	402±3	393±4
HOMA‐IR	0.56±0.04	0.70±0.04*	0.66±0.05	0.62±0.04
Triglyceride, mg/dL	267±27	882±49†	639±50†,§	618±30†
Total cholesterol, mg/dL	76±1	105±2†	95±3†,‡	98±4†
Free fatty acid, mEq/L	218±16	386±37†	303±23*	284±18*,‡
Glucose, mg/dL	152±9	194±8†	175±3*	180±2†
Creatinine, mg/dL	0.35±0.02	0.22±0.02†	0.26±0.01†	0.25±0.01†
Uric acid, mg/dL	1.64±0.05	2.13±0.08†	1.89±0.09*	1.46±0.06§
CCr, mL/min	3.03±0.16	3.91±0.27*	3.14±0.13‡	3.22±0.13‡
Renin activity, ng/mL per h	5.7±0.8	3.0±0.3†	17.1±1.9†,§	18.0±0.6†,§

Data are presented as mean±SEM. CCr indicates creatinine clearance; Con‐DS, control diet–fed DS; DS, Dahl salt sensitive; HFr‐Can, high‐fructose diet and candesartan treatment; HFr‐DS, high‐fructose–fed DS; HFr‐Ena, high‐fructose diet and enalapril treatment; and HOMA‐IR, homeostasis model assessment for insulin resistance.

^*P<0.05, ^†P<0.01 compared with the Con‐DS group.

^‡P<0.05, ^§P<0.01 compared with the HFr‐DS group.