Table 1.

Cardiac Function Parameters for WT and Nrf2^‐/‐ Mice With Endotoxemia

	WT										Nrf2‐/‐
	Veh	rPHB1 only			LPS only			rPHB1 +LPS			Veh	LPS only			rPHB1 +LPS
Age, wks	11.60±0.5	12.25±1.0			11.60±0.5			12.33±0.8			9.50± 0.7	9.25±0.5			9.50±0.6
Weight, g	26.16±2.3	27.60±2.0			26.96±1.0			26.65±1.3			24.35±1.5	23.96±1.0			24.20±1.6
		4 h	8 h	14 h	4 h	8 h	14 h	4 h	8 h	14 h		4 h	8 h	14 h	4 h	8 h	14 h
LVeSD, mm	2.53±0.3	2.46±0.4	2.53±0.3	2.39±0.4	3.49±0.4*	3.01±0.2*	3.19±0.3*	3.29±0.3*	3.15±0.4*	2.12±0.5	2.65±0.3	3.24±0.2*	3.03±0.3*	2.79±0.3	2.82±0.1	2.33±0.2	2.11±0.5
LVeDD, mm	3.99±0.3	3.95±0.4	3.97±0.3	3.86±0.3	4.16±0.4	3.90±0.2	4.14±0.3	4.03±0.2	4.05±0.3	3.57±0.4	4.34±0.3	4.07±0.2	3.88±0.3	3.75±0.3	3.84±0.3	3.69±0.2	3.77±0.3
Heart rate, bpm	463.98±42.6	531.14±24.1	526.04±28.9	505.99±35.1	552.34±40.8*	459.69±22.4	412.35±52.3	565.26±36.0*	497.13±57.9	482.52±46.4	435.33±40.1	527.55±16.1*	365.11±33.8	370.89±44.3	523.14±17.0*	433.76±46.7	431.49±31.3
Stroke volume, μL	46.82±7.3	46.38±6.8	45.64±6.2	44.10±5.3	26.00±4.3*	30.78±4.5*	35.45±4.9*	27.37±7.6*	32.27±6.3*	38.33±6.6	59.17±7.0	30.78±3.4*	29.06±3.3*	30.10±6.7*	33.68±11.5*	38.87±5.9*	45.56±5.6

A 1‐way ANOVA followed by Tukey’s post hoc multiple comparisons test between groups was used to test for differences in main effect of treatment between groups. N, 4–7 mice per group. bpm indicates beats per minute; LPS, lipopolysaccharide; LVeDD, left ventricular end diastolic diameter; LVeSD, left ventricular end systolic diameter; rPHB1, recombinant human prohibitin 1; Veh, vehicle; and WT, wild type.

^*P<0.05 vs untreated mice (Vehicle), for that respective time point and genotype.