Table 2.
Serial Change in Lipid Parameters
|
Baseline (n=101) |
1 mo (n=101) |
P Value | |
|---|---|---|---|
| LDL‐C, mmol/L | 3.1±0.9 | 1.8±0.5 | <0.001 |
| Achieved LDL‐C <1.8 mmol/L, n (%) | … | 53 (52) | … |
| Percent reduction in LDL‐C (%) | … | 40±21 | … |
| Percent reduction in LDL‐C<15%, n (%) | … | 11 (11) | … |
| Total cholesterol, mmol/L | 5.0±1.0 | 3.7±0.6 | <0.001 |
| HDL‐C, mmol/L | 1.2 (1.0–1.5) | 1.2 (1.1–1.6) | 0.003 |
| Mature PCSK9, ng/mL | 225 (187–284) | 312 (265–376) | <0.001 |
| Furin‐cleaved PCSK9, ng/mL | 22 (17–28) | 26 (19–32) | <0.001 |
Continuous variables are expressed as mean±SD, and non‐normally distributed continuous data are summarized as median (interquartile range).
HDL‐C indicates high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; and PCSK9, proprotein convertase subtilisin/kexin type 9.