Table 3.

Logistic Regression Analysis for Predicting Hyporesponse to Statins (Percent Reduction in LDL‐C <15%) by Each PCSK9 Subtypes' Concentration

	Unadjusted Model		Age‐ and Sex‐Adjusted Model		Multivariate‐Adjusted Model*
	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
Mature PCSK9 (per 10, ng/mL)	1.08 (1.01–1.15)	0.02	1.11 (1.03–1.20)	0.009	1.12 (1.01–1.24)	0.03
Furin‐cleaved PCSK9 (per 10, ng/mL)	1.37 (0.88–2.11)	0.16	1.38 (0.89–2.15)	0.15	1.37 (0.73–2.58)	0.33

LDL‐C indicates low‐density lipoprotein cholesterol; OR, odds ratio; and PCSK9, proprotein convertase subtilisin/kexin type 9.

^*Adjusted by sex, age, hypertension, diabetes mellitus, estimated glomerular filtration rate, type of statin, and high‐intensity statin use.