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. 2021 Sep 16;12:724149. doi: 10.3389/fgene.2021.724149

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Copyright © 2021 Kumar and Mandal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagrammatic representation of effects of cholesterol-lowering drugs on Akt in cancer signaling. Statins can act on Akt via inhibition of cholesterol synthesis, EGFR, NOTCH 1, and the promotion of RhoB. Fenofibrate can also act on Akt via inhibition of NF-κB. Inhibition of Akt phosphorylation leads to prevention of radioresistance, cell proliferation, migration, and metastasis of cancer cells and promotion of apoptosis and cell cycle arrest.