TABLE 1.

Clinical studies and their outcomes in cancer treatment by using cholesterol-lowering drugs.

Type of cancer	Cholesterol-lowering drug	Clinical trial phase	Clinical trial number	Status	Outcome	Reference
Lung cancer	Simvastatin	Phase II	NCT00452244	Completed	Improved efficacy of gefitinib	Han et al., 2011
Breast cancer	Atorvastatin	Phase II	NCT00816244	Completed	Anti-proliferative	Feldt et al., 2015
	Simvastatin	Phase II	NCT00334542	Completed	Decreased Estrone sulphate	Higgins et al., 2012
Colorectal cancer	Simvastatin	Phase II	NCT02026583	Completed	Shows comparable clinical efficacy along with XELOX and bevacizumab	Kim et al., 2019
		Phase II		Completed	Increased time to progression	Lee et al., 2009
Prostate cancer	Atorvastatin	–	–	–	Reduced PSA levels	Khosropanah et al., 2011
Pancreatic cancer	Combination of Evolocumab, Atorvastatin, Ezetimibe	Early phase I	NCT04862260	Not yet recruiting	Not yet	Chu de Quebec-Universite Laval, 2021