Table 3.
Histoblood Group Antigen–Blocking Geometric Mean Titers (GMTs) and Proportions of Subjects Achieving Titers of ≥200 Against Norovirus GI.1 and GII.4 Virus-Like Particles
| Antigen, Time | Cohorts A and D |
Cohort B |
Cohort C |
|||
|---|---|---|---|---|---|---|
| GMT (95% CI) | Subjects With GMT ≥200, % | GMT (95% CI) | Subjects With GMT ≥200, % | GMT (95% CI) | Subjects With GMT ≥200, % | |
| GI.1 | ||||||
| Day 0 | 16 (12–22) | 0 | 17 (8–34) | 0 | 17 (11–27) | 0 |
| Day 28 | 260 (166–405) | 61 | 251 (170–370) | 75 | 216 (126–369) | 56 |
| Day 56 | 191 (139–262) | 35 | 276 (171–444) | 63 | 278 (228–338) | 89 |
| GII.4 | ||||||
| Day 0 | 25 (15–41) | 0 | 49 (16–150) | 13 | 57 (16–200) | 33 |
| Day 28 | 249 (161–386) | 56 | 545 (272–1092) | 100 | 293 (171–500) | 67 |
| Day 56 | 172 (123–239) | 35 | 472 (228–979) | 75 | 318 (203–499) | 78 |
Subjects in cohorts A and D were aged 18–49 years, those in cohort B were aged 50–64 years, and those in cohort C were aged 65–83 years.
Abbreviation: CI, confidence interval.