Table 4.
Effect of Secretor Status and Blood Group on Total Immunoglobulin Response Before and After Receipt of Norovirus Vaccine Containing GI.1 and GII.4 Virus-Like Particles
| Variable, Antigen | Day 0 | Day 28 |
Day 56 |
Day 0 | Day 28 |
Day 56 |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| GMT | GMT | GMFRa | GMT | GMFRa | GMT | GMT | GMFRa | GMT | GMFRa | |
| Secretor status | Negative (n = 10) | Positive (n = 25) | ||||||||
| GI.1 | 1576 | 163 840 | 104 | 206 425 | 128 | 3108 | 155 002 | 49.9 | 159 360 | 51.3 |
| GII.4 | 485 | 50 428 | 104 | 44 239 | 69.1 | 10 240 | 114 257 | 11.2 | 117 470 | 11.5 |
| Blood group | B/AB (n = 4) | A/O (n = 31) | ||||||||
| GI.1 | 1076 | 163 840 | 152.2 | 137 772 | 128 | 2863 | 156 675 | 54.7 | 175 599 | 59.7 |
| GII.4 | 1076 | 97 420 | 90.5 | 81 920 | 76.1 | 5120 | 89 584 | 17.5 | 91 952 | 15.3 |
Times correspond to before (day 0) and 4 weeks after the first dose (day 28) and 4 weeks after the second dose (day 56).
Abbreviation: GMT, geometric mean titer.
a Geometric mean fold rise (GMFR) is defined as the geometric mean of the ratio between the titer on the given day and the titer at baseline.