Table 4.
Cognitive performance by quartiles of the modified CAID dementia risk score
| Bottom quartile (Q1) | Q2 | Q3 | Top quartile (Q4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean±SD | β±SE | P | Mean±SD | β±SE | P | Mean±SD | β±SE | P | Mean±SD | β±SE | P | |
| Community sample | ||||||||||||
| MoCA | 23.4±0.6 | ref | - | 23.5±0.7 | 0.2±0.9 | 0.855 | 22.6±0.7 | −0.7±0.8 | 0.455 | 20.1±0.7 | −3.3±0.9 | <0.001 |
| Animals | 19.9±0.8 | ref | - | 17.2±0.8 | −2.7±1.1 | 0.017 | 16.7±0.9 | −3.2±1.2 | 0.008 | 15.0±0.8 | −4.9±1.1 | <0.001 |
| Clinical sample | ||||||||||||
| MoCA | 24.0±0.8 | ref | - | 21.4±0.9 | −2.5±1.2 | 0.038 | 17.6±0.7 | −6.4±1.1 | <0.001 | 14.8±0.9 | −9.1±1.2 | <0.001 |
| Noise | 19.0±0.5 | ref | - | 18.1±0.5 | −0.9±0.7 | 0.207 | 17.1±0.4 | −1.9±0.6 | 0.002 | 16.6±0.5 | −2.4±0.7 | <0.001 |
| Num-F | 7.1±0.2 | ref | - | 7.0±0.2 | −0.1±0.3 | 0.715 | 6.5±0.2 | −0.6±0.3 | 0.025 | 5.8±0.2 | −1.3±0.3 | <0.001 |
| Num-B | 5.0±0.2 | ref | - | 4.9±0.2 | −0.0±0.3 | 0.884 | 4.3±0.2 | −0.7±0.3 | 0.010 | 4.0±0.2 | −1.0±0.3 | 0.002 |
| HVLT-R | 19.5±0.9 | ref | - | 17.1±0.9 | −2.4±1.3 | 0.075 | 12.8±0.7 | −6.7±1.2 | <0.001 | 11.9±1.0 | −7.6±1.3 | <0.001 |
| HVLT-D | 6.9±0.5 | ref | - | 5.2±0.5 | −1.7±0.7 | 0.018 | 2.9±0.4 | −4.0±0.6 | <0.001 | 2.6±0.5 | −4.3±0.7 | <0.001 |
| TMT A | 35.0±5.5 | ref | - | 52.2±5.6 | 17.1±7.9 | 0.030 | 63.7±4.4 | 28.7±7.0 | <0.001 | 76.7±5.8 | 41.6±8.0 | <0.001 |
| TMT B | 69.4±6.2 | ref | - | 102.4±6.7 | 33.1±9.1 | <0.001 | 138.7±5.4 | 69.3±8.2 | <0.001 | 145.5±7.8 | 76.1±9.9 | <0.001 |
| Animals | 18.3±0.8 | ref | - | 16.3±0.8 | −2.0±1.1 | 0.079 | 12.4±0.6 | −5.9±1.0 | <0.001 | 10.6±0.9 | −7.8±1.2 | <0.001 |
| MINT | 14.8±0.3 | ref | - | 14.3±0.3 | −0.5±0.5 | 0.303 | 13.1±0.3 | −1.8±0.4 | <0.001 | 12.9±0.4 | −1.9±0.5 | <0.001 |
| Num-Sym | 41.7±1.8 | ref | - | 32.7±1.9 | −8.9±2.7 | 0.001 | 27.2±1.6 | −14.4±2.4 | <0.001 | 22.5±2.1 | −19.2±2.8 | <0.001 |
| z-score | 4.4±0.6 | ref | - | 3.7±0.6 | −0.7±0.8 | 0.396 | 0.7±0.5 | −3.7±0.8 | <0.001 | −0.4±0.7 | −4.9±0.9 | <0.001 |
Legend: MoCA=MoCA global; Noise=Noise Pareidolia; Num-F=Numbers Forward; Num-B=Numbers Backward; HVLT-R=Hopkins Verbal Learning Test - Recall; HVLT-D=HVLT Delayed; TMA=Trail Making A; TMB=Trail Making B; Animals=Animal Naming; MINT=Multilingual Naming Test; Num-Sym=Number Symbol Coding Task.
Notes: Mean scores are presented in both samples. Unadjusted values. Bolded p values are significant at p<0.005 in the community sample and significant after adjustment for multiplicity of testing with the Bonferroni correction (p<0.004) in the clinical sample.