Table 6.
Risk of cognitive impairment across mCAIDE risk profiles
| Low risk profile (score=0) | Intermediate risk profile (score=7) | High risk profile (score= 14) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Sex | Female | Female | Male | Male | |||||
| Age, years | <65 | 65–72 | 65–72 | ≥73 | |||||
| Education, years | ≥16 | 12–16 | 12–16 | <12 | |||||
| Systolic blood pressure, mmHg | <140 | Scenarios | Scenarios | ≥140 | |||||
| <140 | ≥140 | <140 | <140 | ≥140 | ≥140 | ||||
| Body-mass index, kg/m2 | <30 | <30 | <30 | ≥30 | ≥30 | ≥30 | <30 | ≥30 | |
| High cholesterol, self-reported | No | Yes | No | No | Yes | No | Yes | Yes | |
| Physical activity, mini PPT | Active | Inactive | Inactive | Inactive | Active | Active | Active | Inactive | |
| Risk of … | |||||||||
| Cognitive impairment | Community sample | 12.4% | 27.2% | 53.1% | |||||
| Clinical sample | 3.9% | 16.7% | 49.4% | ||||||
| DLB vs MCI-AD (clinical sample) | 13.6% (ref) | 52.4% (p=0.051) | 81.5% (p=0.043) | ||||||
| VCID vs. MCI-AD (clinical sample) | 2.2% (ref) | 17.5% (p=0.864) | 66.9% (p=0.003) | ||||||
| VCID vs. MCI-DLB (clinical sample) | 5.2% (ref) | 39.4% (p=0.252) | 88.5% (p=0.037) | ||||||
| MCI-AD vs controls (clinical sample) | 25.9% (ref) | 58.4% (p=0.274) | 85.0% (p=0.018) | ||||||
| MCI-DLB vs controls (clinical sample) | 1.1% (ref) | 26.6% (p=0.551) | 92.2% (p=0.035) | ||||||
Notes: Cognitive impairment defined as impairment in both MoCA and Animal Naming in the community sample and as being in the bottom quartile of the global Z-score in the clinical sample. Unadjusted values.