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. 2021 Sep 16;11:729230. doi: 10.3389/fonc.2021.729230

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Copyright © 2021 Huang, Lai, Liao, Cai, Li, Meng, Wang, Mo and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The functional enrichment analysis of ADAM12 was performed with the Metascape tool. (A) GO enrichment analysis data indicated that these genes were mainly enriched in extracellular matrix (ECM) organization, NABA CORE MATRISOME, ECM proteoglycans, NANA MATRISOME ASSOCIATED, and skeletal system development. (B) The KEGG pathway analysis showed enrichment in extracellular matrix organization, NABA CORE MATRISOME, ECM proteoglycans, NANA MATRISOME ASSOCIATED, and skeletal system development. (C) Nodes in the same enrichment network colored by P value, as shown in the legend. The darker the color, the more significant the node (see legend for P value ranges). (D, E) The protein–protein interaction network showed enrichment in extracellular matrix organization, NABA CORE MATRISOME, ECM proteoglycans, NANA MATRISOME ASSOCIATED, and skeletal system development.