Table 3.

Summary of mean pharmacokinetic (PK) values following BUP-XR subcutaneous injection

	Test group and PK values
PK parameter (unit)	Low dose males	High dose males	Low dose females	High dose females
AUC0-t (ng/mL*h)	126	250	86	175
T1/2 (h)	51	78	55	85
CL (L/h)	1.24	1.03	1.46	1.14
Vd (L)	91	116	116	140
Ke (h−1)	0.014	0.089	0.013	0.081
Tmax (h)	24	24	6	24
Cmax (ng/mL)	1.58	2.69	1.12	1.81

BUP-XR dosages = 0.65 and 1.3 mg/kg body weight in low dose group and high dose group, respectively.