TABLE 1.

Nonsynonymous mutation profiles of the Delta variant, lineage B.1.617.2 (strain I), and the Kappa variant, lineage B.1.617.1 (strain II)^a

Geneb	Strain	Genomic changes	Amino acid changes
ORF1ab	I	C1191T, C5051T, C5184T, C6539T, C9891T, T11418C, G14122A, C14408T, G15451A, C16466T, C20320T	P309L, P1596S, P1640L, H2092Y, A3209V, V3718A, G4620S, P4715L, G5063S, P5401L, H6686Y
	II	C4965T, A11201G, C14408T, G16852T, G17523T, A20396G, T20401G	T1567I, T3646A, P4715L, G5530C, M5753I, K6711R, S6713A
S	I	C21618G, G21987A, A22028G, 22029del–22034del, T22917G, C22995A, A23403G, C23604G, G24410A	T19R, G142D, R158G, E156del–F157del, L452R, T478K, D614G, P681R, D950N
	II	C21846T, G21987A, G22022A, T22917G, G23012C, A23403G, C23604G, A24775T	T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
ORF3a	I	C25469T	S26L
	II	C25469T	S26L
M	I	T26767C	I82T
	II	T26767G	I82S
ORF7a	I	C27739T, C27752T, T27638C	L116F, T120I, V82A
	II	T27638C	V82A
ORF8	I	C27972T, 28248del–28253del	Q27,c D119del–F120del
N	I	G28881T, G29402T, A28461G, G29427A	R203M, D377Y, D63G, R385K, S26L
	II	G28881T, G29402T	R203M, D377Y

^aDel, deletion. Bold text indicates mutations that appear in both variants.

^bORF, open reading frame; S, spike; M, membrane; N, nucleocapsid.

^cStop codon.