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LCT domain architecture and mechanism of action. (A) Individual domains are colored as follows: glycosyltransferase domain (GTD) in blue, cysteine protease domain (CPD) in yellow, translocation and receptor-binding domain (T domain) in red, and combined repeating oligopeptide (CROP) in purple. (B) Schematic illustrating the major steps of LCT intoxication of host cells, using TcdB (PDB 6OQ5).
