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LCT gene organization. The PaLoc of C. difficile and PaLoc-like regions of P. sordellii and C. perfringens, first identified in C. difficile strain VPI 10463, P. sordellii strain VPI 9048, and C. perfringens strain ATCC 3626. LCT genes are colored red. Accessory genes are colored as follows: alternative σ factor (tcdR/tcsR/tpeR) in blue, anti-σ factor (tcdC) in purple, and holin-like protein (tcdE/tcsE/tpeE) in yellow.
