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Translocation features of the TcdA T domain. (A) Structure of the TcdA T domain (PDB 4R04), with the evolutionarily conserved translocase colored purple (residues 853 to 1475) and the hydrophobic region (residues 958 to 1137) colored green. (B) Focus on the evolutionarily conserved region and (C) the hydrophobic region without the rest of the T domain. Residues with important functions in translocation identified by Zhang et al. (197) are shown as pink sticks.
