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Structural features of the LCT glycosyltransferase domain. (A) TcdB glycosyltransferase domain (PDB 2BVM) in complex with the cosubstrate and a manganese ion, depicted as green sticks and a sphere, respectively. Residues important for catalytic function are depicted as yellow sticks. Structures of the (B) TcdA (PDB 3SRZ), (C) TcsL (PDB 2VKD), and (D) TcnA (PDB 2VK9) glycosyltransferase domains. The membrane localization domain (MLD) is colored aqua.
