TABLE 10.
LCT-mediated glycosylation of Rho and Ras GTPases and correlated cellular effectsa
| LCT | Cytopathic effect | Cytotoxic effect | Pyroptosis |
|---|---|---|---|
| TcdA | Rho GTPases (Rac) (289) | Rho GTPases (290) | RhoA (260) |
| TcdB | Rho GTPases (Rac) (291) | Rho GTPases (RhoA) (292) | RhoA (258) |
| TcsL | Rho GTPases (Rac) (250, 293) | Ras GTPases ([H/K/N]-Ras) (250) | ND |
| TcsH | Rho GTPases (221, 286) | Rho GTPases (221, 286) | ND |
| TcnA | Rho GTPases (221, 287) | Rho GTPases (221, 287) | ND |
| TpeL | Rho GTPases (Rac) (223) | Ras GTPases (189) | ND |
a
The following strains are used for each LCT: VPI10463 (TcdA, TcdB); VPI 9048 (TcsL); VPI 9048 (TcsH); 590 (TcnA); MC18 (TpeL). ND, not determined.