TABLE 5.
Sequence identity and similarity of LCT translocation and receptor-binding domains
| LCT | % sequence identity (% similarity)a |
||||
|---|---|---|---|---|---|
| TcdA | TcdB | TcsH | TcsL | TcnA | |
| TcdB | 47 (69) | ||||
| TcsH | 79 (92) | 48 (70) | |||
| TcsL | 47 (69) | 77 (88) | 48 (70) | ||
| TcnA | 28 (50) | 28 (51) | 28 (51) | 28 (50) | |
| TpeL | 36 (56) | 33 (56) | 37 (56) | 34 (56) | 28 (47) |
aSequence identity and similarity were calculated using Water (EMBOSS) local alignment. The following boundaries of the LCT T domains were used for sequence comparison: TcdA (802 to 1812), TcdB (800 to 1814), TcsH (802 to 1812), TcsL (800 to 1815), and TcnA (800 to 1822). LCTs are from the following strains: C. difficile VPI 10463, P. sordellii VPI 9048, C. novyi 19402, and C. perfringens JGS1495. Under new subtyping analysis, TcdA and TcdB from C. difficile VPI 10463 are referred to as TcdA1 and TcdB1 (138).