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. 2021 Oct 1;131(19):e149336. doi: 10.1172/JCI149336

Figure 11. Basal ESC requirement for gene expression, remodeling, and functional readouts for PVLD.

Figure 11

(A–D) Levels of mRNA markers for basal cells (A), AT2 cells (B), type 2 immune response (C), and mucus production (D), 49 days after SeV or SeV-UV infection in Krt5-Cre-Ert2 Il33fl/fl mice with or without tamoxifen treatment. (E) PAS and hematoxylin staining of lung sections for the conditions in A. Scale bar: 1 mm. (F) Quantitation of staining of lung sections in E. (G) Immunostaining for Aqp3 and Pdpn under the conditions in A. Scale bar: 1 mm. (H) Immunostaining for Sftpc and Pdpn under the conditions in A. Scale bar: 200 μm. (I) Oximeter levels for blood oxygen saturation (SpO2) under the conditions in A. (J) Values for airway resistance (RRS) at baseline and after inhaled MCh under the conditions in A. Data represent results from a single experiment with 5 mice per condition, and experiments were replicated twice. *P < 0.05, by ANOVA with Bonferroni correction.