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. 2021 Oct 1;131(19):e149336. doi: 10.1172/JCI149336

Figure 12. Basal ESC immune-signaling function in PVLD.

Figure 12

(A) Immunostaining for F4/80 on day 49 after SeV or SeV-UV infection of Krt5-Cre-Ert2 Il33fl/fl mice with or without tamoxifen treatment. Scale bar: 1 mm. (B) Quantitation of staining for the images in A. (C) Dot plot for Cxcl17 gene expression from scRNA-Seq analysis of lung epithelial cells for combined sample conditions (12 and 21 days after SeV infection or PBS challenge). (D) Lung levels of Cxcl17 mRNA for the conditions in A. (E) Immunostaining for Cxcl17 and Aqp3 in lung sections after 49 days under the conditions in A. Scale bar: 400 μm. Data represent results from a single experiment with 5 mice per condition, and experiments were replicated twice. *P < 0.05, by ANOVA with Bonferroni correction.