Table 3.
Toxicity Prediction results of the bioactive compounds using PreADMET Web server
| S/N | Compounds | Carcinogenic test (Mouse) | HERG Inhibition | BBB | PWS (mg/L) | SP | HIA | PPB | BS |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Neoxanthine | Negative | Medium risk | 9.010 | 0.020 | − 0796 | 95.175 | 92.807 | 0.0549 |
| 2 | Violaxanthine | Negative | Medium risk | 9.300 | 0.007 | −0.806 | 96.428 | 91.271 | 0.918 |
| 3 | Betacarotene | Negative | Medium risk | 25.995 | 2.646 | −0.609 | 100.000 | 100.000 | 3.363 |
| 4 | Lutein | Negative | Medium risk | 16.260 | 0.003 | −0.648 | 95.521 | 100.000 | 0.002 |
| 5 | Donepezil | Negative | Medium risk | 0.188 | 6.236 | −3.042 | 97.951 | 84.616 | 5.101 |
Legend: BBB Blood Brain Barrier partition coefficient, PWS Pure Water Solubility, SP Skin Permeability, HIA Human Intestinal Absorption, PPB Plasma Protein Binding, and BS Buffer Solubility