Table 1.

Statistical summary of the datasets utilized in this study.

Dataset	Tissue	Case Samples	Control Samples	DEGs(Pval = 0.05)	DEGs (Pval = 0.05logFC = abs(1))	Raw GSEA	Fisher GSEA
COVID-19 [33]	Peripheral blood mononuclear cells	3	3	4453	2657	3627	446
GSE1297 [34]	Hippocampal CA1 tissue	22	9	2313	238	6094	3998
GSE12685 [35]	Frontal Cortex	6	8	3251	149	6094	3244
GSE28146 [35]	Hippocampal CA1 tissue	22	8	3405	1107	6530	6206
GSE53695 [36]	Human Brain	6	4	701	678	5956	950
GSE53697 [36]	Human Brain	9	8	678	312	5269	794
GSE833 [37]	Spinal cord gray matter	7	4	733	489	4897	4895
GSE4595 [38]	Motor Cortex	11	9	632	431	6544	5855
GSE19332 [39]	Cervical Spinal cord	3	7	4564	2644	6530	6528
GSE52672 [40]	Spinal cord homogenate	10	10	163	80	4643	1464
GSE68605 [41]	motor neurons	8	3	3171	1973	6530	6492
GSE32534 [42]	Pertitumoral neocortex tissue	5	5	2048	451	6530	5174
GSE64810 [43]	Post-mortem Brain	49	20	436	297	5230	748
GSE77558 [44]	iPSCs derived GABA MS-like neurons	6	6	4155	293	6687	4170
GSE79666 [45]	Motor cortex	7	7	1687	607	8568	1884
GSE97100 [46]	iPSC-derived brain microvascular endothelial cells	8	4	2137	757	9434	2204
GSE32915 [47]	White matter brain tissue	12	4	517	202	6560	6497
GSE38010 [48]	Brain Lesion	5	2	1996	1996	8381	1890
GSE52139 [49]	Spinal Cord (periplaque regions)	8	8	2703	1501	6405	6327
GSE7621 [50]	Postmortem human brain	16	9	5949	885	6530	5712
GSE19587 [51]	Post-mortem Brain	6	5	4150	2453	6094	6071
GSE20141 [52]	laser-dissected SNpc neurons	10	8	7094	3614	6530	6530
GSE20333 [53]	Post-mortem human brains	6	6	684	406	5570	5164
GSE28894 [54]	Parkinson's disease brain	55	59	3943	265	6510	4710
GSE42966 [55]	post-mortem substantia nigra	9	6	950	512	6560	6323
GSE68719 [56]	Post-mortem Brain	29	44	664	227	6140	1020