Table 4.
Candidate drugs targeting hub genes.
| Number | Gene | Drug | Interaction types | Score∗ | PubMed ID |
| 1 | AURKA | PACLITAXEL | – | 2 | 12559175 |
| 2 | AURKA | TAMOXIFEN | – | 2 | 24166501 |
| 3 | AURKA | FLUOROURACIL | – | 2 | 25924824 |
| 4 | CCNA2 | ETHINYL ESTRADIOL | – | 2 | 9806355 |
| 5 | EZH2 | DOXORUBICIN | – | 2 | 25605023 |
| 6 | EZH2 | VORINOSTAT | – | 2 | 25605023 |
| 7 | EZH2 | DABRAFENIB | – | 2 | 27135738 |
| 8 | EZH2 | SULFINPYRAZONE | – | 2 | 28135237 |
| 9 | TOP2A | TENIPOSIDE | Inhibitor | 12 | 8702194;16271071;17361331;17514873;11752352;16480143;9426516 |
| 10 | TOP2A | ETOPOSIDE | Inhibitor | 12 | 8823806;9485461;8870683;9494516;9426516 |
| 11 | TOP2A | VINCRISTINE | – | 10 | 9494516 |
| 12 | TOP2A | DOXORUBICIN | Inhibitor | 4 | – |
| 13 | TOP2A | NORFLOXACIN | Inhibitor | 2 | 11752352 |
| 14 | TOP2A | VALRUBICIN | Inhibitor | 6 | 11752352;16019763 |
| 15 | TOP2A | LEVOFLOXACIN | Inhibitor | 2 | 11752352 |
| 16 | TOP2A | ENOXACIN | Inhibitor | 4 | 18471102;11752352;10089819 |
| 17 | TOP2A | DAUNORUBICIN | – | 3 | 9494516 |
| 18 | TOP2A | OFLOXACIN | Inhibitor | 2 | 2847647 |
| 19 | TOP2A | PEFLOXACIN | Inhibitor | 2 | 11752352 |
| 20 | TOP2A | AMSACRINE | Inhibitor | 12 | 1322791;8823806;10691026;8519659;8632768; 11006484;11716434;11752352;11473732;1311390 |
| 21 | TOP2A | PODOFILOX | Inhibitor | 9 | 16061385;1334447;10783066;11752352;1845848;1331331 |
| 22 | TOP2A | DEXRAZOXANE | – | 2 | 12911317 |
| 23 | TOP2A | MITOXANTRONE | Inhibitor | 13 | 10451375;11004693;18687447;11752352; 9631585;9494516;11278845;9426516 |
| 24 | TOP2A | LOMEFLOXACIN | Inhibitor | 2 | 11752352 |
| 25 | TOP2A | EPIRUBICIN | Inhibitor | 6 | 14728934;16234514;17639997 |
| 26 | TOP2A | DACTINOMYCIN | – | 2 | 9494516 |
| 27 | TOP2A | FINAFLOXACIN | Inhibitor | 2 | 25808831 |
| 28 | TOP2A | IDARUBICIN | – | 2 | – |
| 29 | TOP2A | HYDROQUINONE | – | 2 | 15833037 |
∗
The score is the combined number of database sources and PubMed references supporting a given interaction.